Bienvenido a mi blog donde abordo temas de las dos pasiones de mi vida: La dermatología y la Poesía.

Efficacy and Tolerability of Miltefosine for Childhood

Sujit K. Bhattacharya, T. K. Jha, Shyam Sundar, C. P. Thakur, Juergen Engel, Herbert Sindermann, Klaus Junge,
Juntra Karbwang, Anthony D. M. Bryceson, and Jonathan D. Berman

Miltefosine has previously been shown to cure 97% of cases of visceral leishmaniasis (VL) in Indian adults. Because approximately one-half of cases of VL occur in children, we evaluated use of the adult dosage of miltefosin (2.5 mg/kg per day for 28 days) in 80 Indian children (age, 2-11 years) with parasitologically confirmed infection in an open-label clinical trial. Clinical and parasitological parameters were reassessed at the end of treatment and 6 months later. One patient died of intercurrent pneumonia on day 6. The other 79 patients demonstrated no parasites after treatment, had marked clinical improvement, and were deemed initially cured. Three patients had relapse, and 1 patient was lost to follow-up. The final cure rate was 94% for all enrolled patients and 95% for evaluable patients. 

  Bhattacharya_CID-2003_children-study-3206.pdf
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Escrito por Antonio Rondon Lugo el 26 de febrero de 2007 con 0 comentarios.
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